‘The overall aim of our research is to identify and characterize new patterns and mechanisms of genomic alteration in disease’

Research lines

Cancer Tree-of-Life Project

We perform multiplatform sequencing analyses to characterize mutational processes involved in cancer-like phenomena across species in the tree of life. Our goal is to uncover novel and unexpected biological insights into the mechanisms underlying the origin and progression of cancer.

Mutational Mechanisms of Transposable Elements in Cancer

We employ multi-omics approaches to elucidate the patterns and mechanisms by which transposable elements impact the structure and function of the cancer genome.

Somatic Mutation and Evolution in Normal Tissues and Disease

Using cutting-edge genomic sequencing technologies and advanced computational analyses, we investigate the genetic mechanisms driving aging in normal tissues and their relationship to malignant transformation.