Mónica Martínez-Fernández is an investigator funded by the Spanish Association Against Cancer (AECC). Mónica's research has focused on understanding the genomic and epigenomic alterations that confer advantage to tumor cells. She has a solid background in transcriptomics, proteomics, and epigenetics with interest in statistics and bioinformatics. In particular, Mónica has been trained in molecular biology techniques including microarray, RTqPCR, nanostring, and next generation sequencing (NGS). She has experience with mouse models, cell cultures, and human samples (tumor tissue and liquid biopsies). Her current work focuses on understanding the functional impact of regulatory sequences transduction mediated by retrotransposons highly mutagenic in human tumors. This research is expected to improve cancer diagnostic, treatment, and treatment resistance.
In vivo disruption of an Rb-E2F-Ezh2 signaling loop causes bladder cancer
*, Mónica Martínez-Fernández
*, Marta Dueñas, et al.
2014. Cancer Research. 74-22, pp.6565-6642. ISSN 1538-7445. (
Analysis of the Polycomb-related lncRNAs HOTAIR and ANRIL in bladder cancer.
Mónica Martínez-Fernández, Andrew Feber, et al.
2015. Clinical Epigenetics. 7, pp.109.
A Polycomb-mir200 loop regulates clinical outcome in bladder cancer
Mónica Martínez-Fernández, Marta Dueñas, Andrew Feber, et al.
2015 Oncotarget 6-39, pp.42258-42333.
NOTCH pathway inactivation promotes bladder cancer progression. The Journal of Clinical Investigation.
Antonio Maraver, Pablo J. Fernandez-Marcos,...Mónica Martínez-Fernández,.. et al.
2015 JCI 125-2, pp.824-854.
RNA Detection in Urine: From RNA Extraction to Good Normalizer Molecules.
Martínez Fernández, M.; Paramio, JM.; Dueñas, M.
2016 The Journal of Molecular Diagnostics: 18-1, pp.15-37.
Opposing roles of PIK3CA gene alterations to EZH2 signaling in non-muscle invasive bladder cancer.
*, Martínez-Fernández M
*, Dueñas M
*, Rubio C, López-Calderón FF et al.
2017 Oncotarget. 8:10531-10542 . (